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active and we could start to map precisely how the brain circuits that mediate this disease are. >> ellen is ver el el elyn is ig because she was talking about the things like where is it located. she was the first person to find a b biological marker, an area n the brain that was active in depressed measures. do you want to discuss that. >> again we as well as many other investigators using imaging, we're really trying to take groups of people who had classical symptoms and literally see what was wrong on our brains. are areas over active under active, one area or another area. we started to focus not just on one area but one area became very much critical. it's the area called the subclosal sing law. what we found is its activity is overactive in people when they're depressed. there's actually an effect in the frontal lobe, the thinking parts of brain that are under active. so there's almost a tug of war as the patients describe where there's psychic pain, a very active state of suffering that we think is really driven by this subclos subcolossal. >> she is going to show us things in sc
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